Case Studies

OPHTHALMOLOGY The original article was published by Julius T. Oatts, MD, Division of Ophthalmology, Children’s Hospital of Philadelphia and Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA, and colleagues from multiple academic ophthalmology departments including Johns Hopkins University, University of Miami Miller School of Medicine, University of Southern California, Duke University Medical Center, and Medical University of South Carolina. It appeared in Ophthalmology, the journal of the American Academy of Ophthalmology (AAO), in November 2025.

A 92-year-old patient with intermediate AMD and declining vision raised concern for disease progression. OCT and OCT-A imaging with the Optovue Solix revealed large drusenoid PEDs and pigment migration, but no signs of macular neovascularization or geographic atrophy. This case highlights how non-invasive OCT-A enabled accurate diagnosis and confident management without the need for referral or invasive testing.

When clinical decisions fall into medicine’s grey areas, comprehensive diagnostic data can make all the difference. This case highlights how advanced corneal imaging helped guide a critical treatment decision for a young patient with progressive keratoconus—demonstrating the power of deeper data in balancing risk, safety, and long-term vision outcomes.

Neo or no Neo? Widefield OCT-A Reveals Hidden Neovascularization. This case highlights how widefield OCT and OCT-A can uncover occult retinal neovascularization in a patient with complex, multifactorial retinopathy.

In this compelling case, a 77-year-old man with exudative macular degeneration in the right eye initially responded well to monthly anti-VEGF injections but later developed worsening choroidal neovascularization (CNV) and declining vision. OCT and OCT angiography identified an enlarging CNV complex beneath a pigment epithelial detachment despite treatment. Increasing the injection frequency to every two weeks led to anatomical improvement and restoration of vision to 20/25.

OCT-A is changing how clinicians see the retina. This article highlights the key differences between standard OCT and OCT-A, showing how combining structural and blood-flow imaging enables earlier detection, more confident diagnoses, and comprehensive in-office care—making OCT-A an essential tool in the modern eye care practice.  

In this compelling case study, a 75-year-old woman with intermediate age-related macular degeneration (AMD) and a four-year history of non-exudative macular neovascularization (NE-MNV) is closely monitored using advanced OCT-A technology. Despite her report of increased visual distortion and a subtle increase in lesion size, her condition remained stable without signs of exudation. Through serial imaging, home monitoring, and careful follow-up, the case highlights the power of OCT-A in tracking NE-MNV progression and the importance of vigilance in preventing its conversion to an exudative form. How long can a potentially dangerous lesion remain stable—and might it even play a protective role? Read on to discover how modern imaging and personalized care converge in the nuanced management of AMD.

This case study explores the role of anterior segment OCT in fitting a scleral lens for a patient with keratoconus following corneal cross-linking. Despite being limited to one lens due to cost, the patient experienced significant visual improvement. The case underscores how OCT can streamline the fitting process, enhance precision, and support better clinical decisions in specialty contact lens care.