---
title: Repeatability of non-invasive break-up time measures with a new automated dry eye platform in healthy eyes
description: Evaluation of the intrasession repeatability of non-invasive breakup time and tear meniscus height measurements is possible with the VX 120+ and VX 120+ Drye Eye device. This study demonstrates that the device provides objective automated measurements with an acceptable level of intrasession repeatability.
---

[Case Studies ](https://blog.visionix.com/en-us/clinical-studies)

# [Repeatability of non-invasive break-up time measures with a new automated dry eye platform in healthy eyes](https://blog.visionix.com/en-us/clinical-studies/repeatability-of-non-invasive-break-up-time-measures-with-dry-eye-platform)

 Written by [Ainhoa Molina-Martín, Dolores de Fez and David P. Piñero](https://blog.visionix.com/en-us/clinical-studies/author/ainhoa-molina-martín-dolores-de-fez-and-david-p-piñero) | Oct. 18, 2022

**Abstract**

**Purpose:** To evaluate the intrasession repeatability for non-invasive break-up time (NIBUT) and tear meniscus height (TMH) measurements provided by a new multi-diagnostic platform, and to assess the interobserver reproducibility of TMH measures.

**Methods:** Twenty-one healthy eyes of 21 patients (ages 23–65 years) were enrolled. A complete eye examination was performed in all cases with Visionix’s VX 120+ dry eye device, including an analysis with the new Dry Eye module, performing three consecutive measurements. The within-subject standard deviation (Sw) and Bland– Altman plots were used to assess intrasession repeatability. Differences between examiners for TMH were also analyzed.

**Results: **No statistically significant differences were found between repeated measures of NIBUT (time associated with the first break) and TMH (p 0.05). However, significant differences were found for NIBUT50% (time associated with half of breaks of the tear film) (p ≤0.05). Mean Sw was 0.9 s, 1.4 s and 0.05 mm for NIBUT, NIBUT50% and TMH, respectively. Ranges of agreement between consecutive measures were below 3.5 s and 4.5 s for NIBUT and NIBUT50%, respectively, and below 0.16 mm for TMH. Furthermore, no significant differences were found between examiners in TMH measure, with an inter-examiner range of agreement of 0.12 mm.

**Conclusions:** The new dry eye platform of the VX 120+ Dry Eye  platform evaluated provides objective automated measures of NIBUT and TMH, with acceptable level of intrasession repeatability for clinical screening purposes.

**Keywords**: Dry eye, VX 120+, VX 120+ Dry Eye, Non-invasive tear film break-up time NIBUT, Tear meniscus height.

[View full post](https://blog.visionix.com/en-us/clinical-studies/repeatability-of-non-invasive-break-up-time-measures-with-dry-eye-platform)

```json
{
  "@context" : "http://schema.org",
  "@type" : "BlogPosting",
  "author" : {
    "@type" : "Person",
    "name" : "Ainhoa Molina-Martín, Dolores de Fez and David P. Piñero"
  },
  "dateModified" : "2022-10-18T13:02:07.769Z",
  "datePublished" : "2022-10-18T13:02:07Z",
  "headline" : "US_CS_Diagnostic_Repeatability of non-invasive break-up time measures with a new automated dry eye platform in healthy eyes",
  "image" : {
    "@type" : "ImageObject",
    "height" : 2250,
    "url" : "https://25345637.fs1.hubspotusercontent-eu1.net/hubfs/25345637/Hubspot%20images-1.jpg",
    "width" : 4500
  },
  "mainEntityOfPage" : "https://blog.visionix.com/en-us/clinical-studies/repeatability-of-non-invasive-break-up-time-measures-with-dry-eye-platform",
  "publisher" : {
    "@type" : "Organization",
    "logo" : {
      "@type" : "ImageObject",
      "height" : 60,
      "url" : "/hs/hsstatic/content_shared_assets/static-1.4092/img/default-amp-logo.png",
      "width" : 60
    },
    "name" : "Case Studies"
  }
}
```